Not sure if I'm in the right thread here, but if you're looking for wine lockers for Python and VBS, I've used PyInstaller and AutoIt in the past. Both worked pretty well for my use cases. Anyone have any experience with these or better alternatives?
I've used pyusb for Windows and pyserial for Raspberry Pi, both have been solid options for working with USB devices in Python. pyusb supports Win and Linux, while pyserial is more geared for serial communication.